DOGEVERA RESEARCH · Progetto Research 002
HMB nei cani: studi canini e affermazioni commerciali
Due dataset collegati, frutto di una mappa delle evidenze preregistrata. Il primo elenca gli 11 record tratti da 9 pubblicazioni o brevetti in cui ai cani è stato somministrato HMB (β-idrossi-β-metilbutirrato) per via orale, con popolazione, disegno, dose, durata, risultati e finanziamento. Il secondo riporta parola per parola 32 affermazioni sull'HMB nei cani tratte da 19 pagine commerciali, con la fonte citata da ciascuna, se tale fonte esiste e se la sua popolazione corrisponde ai cani a cui l'affermazione si riferisce.
Per ricercatori, veterinari e lettori che esaminano le evidenze pubblicate. Questi dataset non aggregano risultati di efficacia né valutano l’efficacia dei prodotti; il dataset HMB verifica anche le affermazioni commerciali rispetto alle fonti citate.
Queste risorse servono a rendere più agevole l'esame delle evidenze pubblicate. Non sostituiscono il parere veterinario né la ricerca sottoposta a revisione tra pari.
Se dietro un prodotto non c'è uno studio sui cani, ciò non significa che il prodotto non funzioni. Dogevera vende un integratore di HMB per cani; la sua pagina prodotto è stata esaminata per prima, con le stesse regole di tutte le altre pagine.
Verificato dall'autore: il record dell'abstract IAVRPT 2023 sull'HMB dopo chirurgia ortopedica è stato verificato dall'autore dello studio, il Dr. Morito Ogasawara (Animal Rehabilitation Medicine Laboratory). La verifica riguarda solo quel record e non costituisce un'approvazione di Dogevera o dei suoi prodotti.
Record degli studi
I campi riproducono il CSV pubblicato in inglese. Le celle vuote restano vuote; consulta il dataset completo e il README per metodi e limiti.
| Record | Studio | Anno | Cani | Forma / prodotto | Formulazione | Dose riportata | Durata | Confronto | Finanziamento | Fonte |
|---|---|---|---|---|---|---|---|---|---|---|
| R002-01 | Nghiem PP, Rutledge AM, Tehas K, Kaderli C, et al. Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study. Sci Rep 15:4026. | 2025 | 6 | Bulk Supplements (gelatin capsules in pill pockets) | Calcium HMB powder | 3 g daily | 28 days per period | Placebo | No funding statement found in PMC full text | doi:10.1038/s41598-025-88651-8; PMID 39894866; PMC11788438 |
| R002-02 | Fuller JC Jr, Rathmacher JA. Calcium beta-hydroxy-beta-methylbutyrate improves canine performance in greyhounds and mushing dogs. Open Vet J 16(6):3759–3769. (Study 1) | 2026 | 37 | Not reported | Calcium HMB | 1 g daily | 12-week race meet | 5 g dextrose–electrolyte mixture | MTI Biotech, Inc. (Ames, IA) | doi:10.5455/OVJ.2026.v16.i6.47 |
| R002-03 | Fuller JC Jr, Rathmacher JA. Open Vet J 16(6):3759–3769. (Study 2) | 2026 | 22 | Metabolic Technologies, Ames, IA (four 250 mg capsules in morning feed) | Calcium HMB | 1 g daily | From at least 2 weeks before competition and throughout | Unsupplemented team (allocation by team membership and trainer preference) | MTI Biotech, Inc. | doi:10.5455/OVJ.2026.v16.i6.47 |
| R002-04 | Freire TGB. Uso de cálcio 3-hidroxi-3-metilbutirato em programa de perda de gordura em cães idosos. MSc dissertation, UNESP Jaboticabal (advisor Carciofi AC). | 2025 | 20 completed | Not reported | Calcium HMB (in diet, with vitamin D) | Not in public partial version | Until 20% body-weight reduction (programme length not in partial version) | Control diet | CAPES scholarship; acknowledgements thank "empresa patrocinadora TSI" | UNESP repository 8ed109db-f247-4f61-8f97-b1ef51fe0fed |
| R002-05 | Fenerick JC. Efeitos do emagrecimento e uso de β-hidroxi-β-metilbutirato na aptidão aeróbia de cães obesos. Dissertation, UNESP. | 2025 | 18 | Not reported | HMB in diet (form not stated in available text) | 87 ± 8.7 mg/kg metabolic body weight | Until 20% body-weight loss | Control weight-loss diet | Acknowledgements thank "TSI Group pelo apoio financeiro" | UNESP repository bitstream 87cf8452-43bb-4a21-95f8-739d280885d2 |
| R002-06 | Rychlik A, Nieradka R, Kander M, et al. The effectiveness of natural and synthetic immunomodulators in the treatment of inflammatory bowel disease in dogs. Acta Vet Hung 61(3):297–308. | 2013 | 28 | Not reported | HMB extruded into food | Not reported | 42 days | β-1,3/1,6-D-glucan; levamisole | Not reported | doi:10.1556/avet.2013.015; PMID 23921342 |
| R002-07 | Ogasawara M, Fushimi T. Effects of β-hydroxy-β-methylbutyrate on muscle mass of dogs who underwent orthopedic surgeries. Acta Vet Scand 65(Suppl 1):PO.22 (IAVRPT Symposium 2023 abstract). | 2023 | 18 | PE Muscle Booster (QIX, Japan): per 1 g, calcium HMB 200 mg, creatine 300 mg, water-soluble elastin 10 mg, squid-cartilage chondroitin extract 30 mg (manufacturer page) | Calcium HMB in a multi-ingredient powder | 0.2 g/kg/day (author, email 2026-10-12) | 30 days post-operatively (measured days 0, 4, 10, 30) | No HMB | Not reported | Acta Vet Scand 2023;65(Suppl 1):PO.22; PMC10722699 |
| R002-08 | Fuller J, Rathmacher J, Harris E, Baier S (Metabolic Technologies LLC). Compositions and methods of use of β-hydroxy-β-methylbutyrate (HMB) for joint stability. Patent CA3011364A1 (family: US20210077439A1, JP7611111B2). | 2017 (publication; priority 2016) | 1 | Not reported | Calcium HMB capsules | 2 g/day (two 1 g doses) | About 2 months, paused ~2 weeks, then resumed (total not stated) | None | Patent applicant Metabolic Technologies LLC | CA3011364A1 |
| R002-09 | Zhu D, Lu J, Zhao X, et al. (Jiangsu Agri Animal Husbandry Vocational College). Nutritional paste for pet dogs with renal failure and preparation method thereof. Patent CN110710600A. (Experiment: surgically induced CRF model) | 2020 (publication; filed 2019) | 20 | Paste examples 2, 3, 6 | Calcium HMB in a nutritional paste | Paste 6 g/kg body weight (with normal diet); CaHMB share 2–5 parts by weight (preferred formula 4 parts of ~281.6) | 4 weeks | Normal diet (model group) | Not reported | CN110710600A |
| R002-10 | CN110710600A (as R002-09). (Experiment: client dogs with chronic renal failure) | 2020 (publication; filed 2019) | 24 | Paste example 2 | Calcium HMB in a nutritional paste | Paste (example 2) 6 g/kg body weight, morning and evening | 60 days follow-up | Ordinary diet | Not reported | CN110710600A |
| R002-11 | Jaśkiewicz A, et al. Holistic management of renal nephroblastoma in a juvenile dog with severe cachexia: a case report. Med Weter 78(12):651–655. | 2022 | 1 | Not reported | 3-hydroxy-3-methylbutyric acid (form otherwise not stated) | Not reported | Not reported | None | Not reported | doi:10.21521/mw.6688 |
Verifica delle affermazioni commerciali
Le affermazioni di terzi provengono dalle pagine indicate qui sotto. I diritti su tali fonti possono essere distinti dalla licenza CC BY 4.0 del dataset.
| Affermazione | Fornitore | URL della fonte | Affermazione registrata | Fonte citata | Fonte reperibile | Popolazione della fonte | Popolazione corrispondente | Livello di evidenza |
|---|---|---|---|---|---|---|---|---|
| C01 | Dogevera (ViralMomentum LLC) | https://dogevera.com/products/muscle-strength-recovery-soft-chews-for-dogs | precisely specified daily muscle-support formula for active and aging dogs, built around 150 mg calcium HMB per 2-chew reference serving | n/a | n/a | no | none | |
| C02 | VetriScience | https://www.amazon.com/dp/B0DSGFSF6X | Formula features HMB for mobility support | n/a | n/a | no | none | |
| C03 | VetriScience | https://www.amazon.com/dp/B0DSGFSF6X | myHMB, the foundational ingredient of our powerful new muscle powder for dogs, has been clinically proven to help slow age-related muscle loss, helps to increase exercise endurance for longer walks and more play, and promotes healthy recovery after exercise or surgery, injury, or other periods of restricted movement. | "clinically proven" (no study named) | n/a | n/a | unclear | untraceable |
| C04 | Wonder Paws | https://www.amazon.com/dp/B0H6GYDRV8 | uses clinically studied myHMB, which is a premium metabolite shown to help increase muscle mass and strength, retain muscle mass, and improve recovery from injury or surgery. | "clinically studied" (no study named) | n/a | n/a | unclear | untraceable |
| C05 | Wonder Paws | https://www.amazon.com/dp/B0H6GYDRV8 | a natural metabolite shown in both humans and pets to help reduce muscle loss, increase muscle mass and strength, while supporting overall joint health. | "shown in both humans and pets" (no study named) | n/a | n/a | unclear | untraceable |
| C06 | NaturVet | https://www.amazon.com/dp/B0GT25BH7K | these soft chews use myHMB to assist with muscle recovery and strength for active dogs of all sizes and life stages | n/a | n/a | no | none | |
| C07 | AminAmend | https://www.amazon.com/dp/B0DZ8P56Q1 | It helps reduce muscle loss, promotes recovery, and maintains strength and mobility with ingredients like HMB and Vitamin D3. | "Scientifically Proven" tab heading; "clinically researched ingredients" (no study named) | n/a | n/a | unclear | untraceable |
| C08 | AminAmend | https://www.amazon.com/dp/B0DZ8P56Q1 | Many pet parents notice improvements in mobility and energy within a few weeks. | n/a | n/a | no | none | |
| C09 | Native Pet | https://www.amazon.com/dp/B0FS247J2S | HMB helps preserve muscle around joints | "four clinically studied joint-support ingredients" (no study named) | n/a | n/a | unclear | untraceable |
| C10 | X100BEST | https://www.amazon.com/dp/B0HJZWKJKG | HMB is a metabolite of the essential amino acid leucine that supports healthy muscle maintenance, daily strength and an active lifestyle. | n/a | n/a | no | none | |
| C11 | Replenish | https://www.amazon.com/dp/B0HDZXL71N | Formulated with HMB to help preserve lean muscle mass, improve endurance, and enhance recovery after activity. | "scientifically developed formula" (no study named) | n/a | n/a | unclear | untraceable |
| C12 | CPN (Vertex) | https://www.amazon.com/dp/B08MH1XZRJ | Loaded with essential vitamins, HMB, glucosamine, chondroitin, and probiotics, Vertex keeps joints flexible and energy high | n/a | n/a | no | none | |
| C13 | MuscleX | https://www.amazon.com/dp/B0G4JZ7YYZ | Helps Reduce Muscle Loss Due to Normal Aging and Improves Recovery from Injury | n/a | n/a | no | none | |
| C14 | MuscleX | https://www.amazon.com/dp/B0G4JZ7YYZ | a proven and clinically tested combination of dietary supplements that prevents muscle protein breakdown and supports muscle protein synthesis. | "proven and clinically tested" (no study named) | n/a | n/a | unclear | untraceable |
| C15 | MuscleX | https://www.amazon.com/dp/B0G4JZ7YYZ | HMB has been clinically studied for more than 20 years and has been shown to improve muscle protein synthesis and prevent muscle protein breakdown. | "clinically studied for more than 20 years" (no study named) | n/a | n/a | unclear | untraceable |
| C16 | Dr. Bill's | https://www.amazon.com/dp/B0752XQFBC | Includes HMB, essential amino acids, and collagen to promote muscle retention, connective tissue strength, and faster recovery, ideal for aging, athletic, or recovering dogs. | n/a | n/a | no | none | |
| C17 | AminAmend | https://www.amazon.com/dp/B0DZDDD3Z1 | HMB helps support normal muscle maintenance and dietary protein use when paired with a balanced diet | n/a | n/a | no | none | |
| C18 | Dr. Bill's | https://www.amazon.com/dp/B075HBRBX6 | Formulated to support muscle strength, endurance, normal metabolism, and healthy skin and coat | n/a | n/a | no | none | |
| C19 | MuscleX | https://www.amazon.com/dp/B0G4G4XY4V | Helps Reduce Muscle Loss Due to Normal Aging & Improves Recovery from Inj | n/a | n/a | no | none | |
| C20 | Wonder Paws | https://www.amazon.com/dp/B0FYJLJM58 | made with a patented form of natural metabolite HMB, this formula helps reduce muscle loss and support lean mass. | n/a | n/a | no | none | |
| C21 | VetriScience (FoodScience LLC) | https://www.vetriscience.com/hmb-healthy-muscle-strength.html | Research has shown that HMB (β-hydroxy β-methylbutyrate) helps to support lean muscle mass and maintain healthy muscle during aging.1 | Superscript footnote "1"; no reference list found on the page | n/a | n/a | unclear | untraceable |
| C22 | VetriScience (FoodScience LLC) | https://www.vetriscience.com/hmb-healthy-muscle-strength.html | HMB supports exercise endurance for longer walks and may help with healthy recovery after surgery, injury, or periods of limited movement or crate rest. | n/a | n/a | no | none | |
| C23 | VetriScience (FoodScience LLC) | https://www.vetriscience.com/hmb-healthy-muscle-strength.html | It's one of the most clinically tested ingredients to help slow age-related muscle loss | "most clinically tested" (no study named) | n/a | n/a | unclear | untraceable |
| C24 | TSI Group (ingredient supplier, myHMB) | https://tsigroupltd.com/milestone-study-provides-strong-evidence-for-how-hmb-supports-healthy-aging-in-pets/ | Milestone Study Provides Strong Evidence for How HMB Supports Healthy Aging in Pets | Nghiem PP et al. 2025. Sci Rep 15:4026. doi:10.1038/s41598-025-88651-8 | partly | disease model (Duchenne muscular dystrophy dogs, about 2–3 years old, n = 6) | no | canine disease model |
| C25 | TSI Group (ingredient supplier, myHMB) | https://tsigroupltd.com/milestone-study-provides-strong-evidence-for-how-hmb-supports-healthy-aging-in-pets/ | Now a new study, published in Nature, is the first to demonstrate HMB’s ability to improve daily activity and protein metabolism in dogs with clinically relevant muscle loss. | Nghiem PP et al. 2025. Sci Rep 15:4026. doi:10.1038/s41598-025-88651-8 | partly | disease model (DMD dogs, n = 6) | unclear | canine disease model |
| C26 | TSI Group (ingredient supplier, myHMB) | https://tsigroupltd.com/milestone-study-provides-strong-evidence-for-how-hmb-supports-healthy-aging-in-pets/ | It is well positioned as a scientifically validated solution for muscle preservation and healthy aging in companion animals. | Nghiem PP et al. 2025. Sci Rep 15:4026. doi:10.1038/s41598-025-88651-8 | partly | disease model (DMD dogs, n = 6) | no | canine disease model |
| C27 | TSI Group (myHMB) | https://myhmb.com/applications/pet/ | A new study shows that HMB supports increased daily activity and healthy protein metabolism in pets. | 'TELL ME MORE' link to TSI press release (G02) -> Nghiem PP et al. 2025. Sci Rep 15:4026. doi:10.1038/s41598-025-88651-8 | yes | disease model (DMD dogs, n = 6) | no | canine disease model |
| C28 | TSI Group (myHMB) | https://myhmb.com/applications/pet/ | HMB attenuates exercise-induced muscle damage from intense performance (greyhound racing and Iditarod sled dogs) similar to humans | n/a | n/a | no | none | |
| C29 | TSI Group (myHMB) | https://myhmb.com/applications/pet/ | Thankfully, what has been scientifically proven to help humans has also been proven to help our companion animals! | no study named | n/a | n/a | unclear | untraceable |
| C30 | TSI Group (myHMB) | https://myhmb.com/applications/pet/ | Therefore, supplementing with HMB can improve mobility, strength, stability and overall quality of life for humans and our companions alike. | "numerous studies published in humans" | n/a | human | no | human |
| C31 | Platinum Performance | https://www.platinumperformance.com/dogs-cats/dog-cat-conditions/dog-muscle-health-recovery | HMB is involved in protein synthesis and has been shown to increase muscle mass, prevent muscle from breaking down and/or assist in muscle repair. | "has been shown" (no study named) | n/a | n/a | unclear | untraceable |
| C32 | Platinum Performance | https://www.platinumperformance.com/dogs-cats/dog-cat-conditions/dog-muscle-health-recovery | it can significantly reduce recovery time | n/a | n/a | no | none |
Come citare
Tang, M. (2026). HMB in dogs: canine study dataset and claims audit (Dogevera Research 002) (Version 1.0) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.23525238
Licenza: CC BY 4.0Download e documentazione
Dichiarazione di trasparenza
Dogevera è un'azienda commerciale dedicata al benessere canino. Vende prodotti a base di cozza verde, oggetto del Progetto Research 001, e un integratore contenente HMB, oggetto del Progetto Research 002. Dogevera Research è un'iniziativa di organizzazione delle evidenze gestita da Dogevera e riporta ciò che gli studi mostrano, qualunque sia la direzione dei risultati. Salvo indicazione esplicita, gli autori degli studi citati non hanno esaminato né approvato queste risorse e non hanno partecipato alla loro preparazione. Le correzioni sono benvenute all'indirizzo morty@dogevera.com e verranno riconosciute.